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. 2013 Jul 23;4(4):e00382-13. doi: 10.1128/mBio.00382-13

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Copyright © 2013 Cook et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 6 — Native SHP production can modulate cross-species gene expression when grown in coculture. (A) GAS reporter strain BNL177 was mixed with GBS strains that either produced (A909) or did not produce (BLC101) SHP1520. Coculture with A909 but not BLC101 induced expression of the P_shp2 reporter. BNL177 cultured alone was included as a control. (B) The GBS reporter strain BLC101(pSar110) was mixed with GAS strains in which the Rgg2/3 system is known to be highly induced (JCC131) or not induced (BNL158). Coculture with JCC131 but not BNL158 induced robust expression of the P_shp1520 reporter. BLC101(pSar110) cultured alone was included as a control. Coculture did not detectably inhibit growth of either GAS or GBS compared to growth in pure culture (data not shown). Data are shown as a function of relative light units (CPS/OD₆₀₀) versus OD₆₀₀, with the OD₆₀₀ values being representative of total culture density. Each graph is representative of at least 3 biological replicates.