. 2013 Jul 23;4(4):e00281-13. doi: 10.1128/mBio.00281-13

TABLE 1 .

Daptomycin-susceptible and -resistant Enterococcus faecalis strains and derivatives

Enterococcus faecalis strain	MIC (µg/ml) of DAP			MIC (µg/ml) of DAP-BDP^b	Predicted amino acid change
Enterococcus faecalis strain	MH^a	BHI^a	TSB^a	MIC (µg/ml) of DAP-BDP^b	Cls^c	LiaF^d	GdpD^e
S613	0.5	3	2	8	None	None	None
R712	8	64	64	32	Deletion of Lys at position 61	Deletion of Ile at position 177	Deletion of Ile at position 170
S613∆_liaF177	3	16	16	16	None	Deletion of Ile at position 177	None
S613∆_gdpD170	0.75	3	2	8	None	None	Deletion of Ile at position 170
S613∆_{liaF177gdpD170}	3	24	16	16	None	Deletion of Ile at position 177	Deletion of Ile at position 170
S613∆_{liaF177gdpD170cls61}	6	64	64	32	Deletion of Lys at position 61	Deletion of Ile at position 177	Deletion of Ile at position 170

^{^a}

The MIC of daptomycin was determined by the use of Etest (bioMérieux) on the indicated medium.

^{^b}

The MIC of BODIPY-labeled daptomycin (BDP-DAP) was determined by broth microdilution.

^{^c}

Cls, cardiolipin synthase.

^{^d}

LiaF, lipid II-interacting-antibiotic protein.

^{^e}

GdpD, glycerophosphoryl diester phosphodies terase.