FIG 3 .

In vivo

efficacy of toxtazins A and B. Asterisks denote the statistical significance of a group relative to the DMSO control. NS, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001. (A) Number of V. cholerae organisms recovered from mice orogastrically inoculated with 10⁶ wild-type V. cholerae organisms and treated with either DMSO or 0 µg, 20 µg, 40 µg, or 60 µg toxtazin A. (B) Number of V. cholerae organisms recovered from 3-ml cultures grown overnight with the same inocula and boosters as the mice. (C) Number of V. cholerae recovered from mice orogastrically inoculated as described for panel A and treated with DMSO or 100 µg or 200 µg toxtazin B. (D) Number of V. cholerae organisms recovered from 3-ml cultures grown overnight with the same inocula and boosters as the mice.