Table 1. AR-positive rate after DHT-PROTAC treatment in LNCaP cells.

DHT-PROTAC concentration (μmol L−1)	Positive	Negative	Total	Positive rate (%)
0	165	12	177	93.22
10	191	32	223	85.65
100	179	110	289	61.94
1 000	3	172	175	1.71

Abbreviations: AR, androgen receptor; DHT-PROTAC, dihydrotestosterone-based proteolysis-targeting chimeric molecules. LNCaP cells were treated with 0, 10, 100 and 1 000 μmol L⁻¹ DHT-PROTAC for 4 h, respectively, and then fixed for IHC. AR-positive and -negative cells were calculated in at least five random fields (400 ×). Fisher's exact probability test was used to evaluate the positive rate by using SAS 6.12 statistical software (P = 5.27 × 10⁻⁹⁹ < 0.05).