Table 1. Effect of diazepam on sleep.
| WT
|
MUT
|
Difference Dz - Veh
|
||||
|---|---|---|---|---|---|---|
| Veh | Dz | Veh | Dz | WT | MUT | |
| Sleep latency | 33.1 (2.7) | 24.6 (3.9)* | 30.1 (2.5) | 15.7 (2.8)* | −8.5 (3.3) | −14.4 (3.7) |
| Waking | 30.5 (1.8) | 30.2 (2.8) | 38.3 (1.9) | 31.0 (2.1)* | −3.3 (2.4) | −7.2 (1.4)† |
| NREM sleep | 57.7 (1.3) | 59.4 (2.5) | 52.3 (1.9) | 60.8 (1.8)* | 1.6 (2.5) | 8.4 (1.5)† |
| REM sleep | 11.8 (0.6) | 10.5 (0.6)* | 9.4 (0.6) | 8.2 (0.5) | −1.3 (0.3) | −1.2 (0.5) |
| REM sleep/TST | 16.9 (0.6) | 15.0 (0.7) | 15.3 (0.1) | 11.8 (0.1)* | −1.9 (0.1) | −3.4 (1.0) |
Mean sleep latency (minutes), vigilance states (% of total recording time), and REM sleep per total sleep time (REM sleep/TST). Mean 12-h values (SEM) after vehicle (Veh; 0.3% Tween 80) and diazepam (Dz; 3 mg/kg i.p.) in wild-type mice (WT; n = 8) and α2 (H101R) mutants (MUT; n = 7). *, P < 0.05, Dz vs. Veh within genotype, two-tailed paired t test. †, P < 0.05, MUT vs. WT, two-tailed t test.