Table 3. Persistent hypernociception: Effect of l-NMMA, ODQ, and KT5823 on the intensity of hypernociception of the quiescent phase induced by antinociceptive drugs.

			Quiescent phase
Treatment	Before	After	l-NMMA	ODQ	KT
Dip	14.1 ± 0.6	6.5* ± 0.7	6.5* ± 0.7	4.1* ± 1.2	6.9* ± 0.3
SNAP	15.6 ± 0.7	6.4* ± 0.5	−	6.4* ± 0.5	7.2* ± 0.5
8-Br-cGMP	15.2 ± 0.6	7.9* ± 0.3	−	−	8.7* ± 0.7

Before and after columns are the controls and values of the treatments shown in Table 2, made in the persistant phase. Ten days after the induction of the quiescent phase by dipyrone (Dip), SNAP, and 8-Br-cGMP, the paws were injected with l-NMMA (50 μg), ODQ (8 μg), and KT5823 (KT, 1.5 μg). Measurements made 90 min after the injections show no significant differences in the quiescent phase between the control values (After) and the inhibitors tested (^*, P < 0.05). The data (in seconds) are the means (±SEM) of five animals per group.