TABLE 2.
ENDOTHELIAL MICROPARTICLE COUNTS BY COPD SEVERITY
| Control Subjects (n = 76) | Mild (n = 39) | Moderate (n = 45) | Severe (n = 19) | P Value for Linear Trend Across COPD Severity | |
|---|---|---|---|---|---|
| CD31+ endothelial microparticles per microliter, log-transformed | |||||
| Mean (SD) |
7.11 (0.58) |
7.12 (0.49) |
7.26 (0.71) |
7.52 (0.51) |
0.01 |
| Predicted mean, model 1* |
7.10 |
7.30 |
7.27 |
7.49† |
0.02 |
| Predicted mean, model 2‡ |
7.10 |
7.32† |
7.30 |
7.51† |
0.01 |
| Predicted mean, model 3§ |
7.07 |
7.31† |
7.27 |
7.40† |
0.03 |
| CD51+ endothelial microparticles per microliter, log-transformed | |||||
| Mean (SD) |
6.80 (0.79) |
6.91 (0.68) |
6.94 (0.78) |
7.17 (0.83) |
0.07 |
| Predicted mean, model 1 |
6.80 |
7.06 |
6.89 |
7.00 |
0.43 |
| Predicted mean, model 2 |
6.80 |
7.08 |
6.94 |
7.02 |
0.80 |
| Predicted mean, model 3 |
6.71 |
7.12† |
6.85 |
6.83 |
0.47 |
| CD62E+ endothelial microparticles per microliter, log-transformed | |||||
| Mean (SD) |
5.98 (0.62) |
6.09 (0.68) |
6.02 (0.71) |
6.35 (0.69†) |
0.047 |
| Predicted mean, model 1 |
5.98 |
6.15 |
6.11 |
6.53† |
0.05 |
| Predicted mean, model 2 |
5.98 |
6.16 |
6.12 |
6.54† |
0.05 |
| Predicted mean, model 3 | 5.98 | 6.22 | 6.11 | 6.51† | 0.03 |
Definition of abbreviations: COPD = chronic obstructive pulmonary disease.
*
Model 1 adjusted for age, sex, race and ethnicity, and cohort.
†
P value less than 0.05, compared with control subjects.
‡
Model 2 adjusted for variables in model 1 in addition to smoking status, and pack-years.
§
Model 3 adjusted for variables in model 2 in addition to educational attainment, body mass index, height, weight, diabetes mellitus, hypertension, oxygen saturation, white blood cell count, sleep apnea, high-density lipoprotein, and statin use.