TABLE 3.
PREDICTED MEAN COUNTS OF ENDOTHELIAL MICROPARTICLES BY QUINTILE OF PERCENTAGE OF EMPHYSEMATOUS LUNG ON COMPUTED TOMOGRAPHY
| N = 180 | Computed Tomography Percent Emphysema |
Difference Per Log Increase in Percent Emphysema (95% CI) | P Value | ||||
|---|---|---|---|---|---|---|---|
| Quintile 1 (n = 36) | Quintile 2 (n = 36) | Quintile 3 (n = 36) | Quintile 4 (n = 36) | Quintile 5 (n = 36) | |||
| CD31+ endothelial microparticles per microliter, log-transformed | |||||||
| Mean (SD) |
7.09 (0.50) |
7.27 (0.49) |
7.07 (0.59) |
7.13 (0.55) |
7.41 (0.79) |
|
0.13 |
| Predicted mean, model 1* |
7.09 |
7.14 |
7.22 |
7.31 |
7.57 |
0.082 (0.019 to 0.145) |
0.01 |
| Predicted mean, model 2† |
7.07 |
7.13 |
7.21 |
7.32 |
7.60 |
0.089 (0.026 to 0.152) |
0.006 |
| Predicted mean, model 3‡ |
7.01 |
7.06 |
7.11 |
7.18 |
7.27 |
0.075 (0.002 to 0.149) |
0.045 |
| CD51+ endothelial microparticles per microliter, log-transformed | |||||||
| Mean (SD) |
6.86 (0.69) |
7.13 (0.68) |
6.75 (0.77) |
6.74 (0.67) |
7.02 (0.98) |
|
0.85 |
| Predicted mean, model 1 |
6.81 |
6.85 |
6.90 |
6.98 |
7.17 |
0.059 (−0.032 to 0.150) |
0.20 |
| Predicted mean, model 2 |
6.80 |
6.84 |
6.91 |
6.99 |
7.20 |
0.068 (−0.023 to 0.159) |
0.14 |
| Predicted mean, model 3 |
6.88 |
6.91 |
6.93 |
6.96 |
7.00 |
0.032 (−0.088 to 0.152) |
0.60 |
| CD62E+ endothelial microparticles per microliter, log-transformed | |||||||
| Mean (SD) |
5.94 (0.60) |
5.92 (0.68) |
6.05 (0.73) |
6.11 (0.56) |
6.22 (0.71) |
|
0.03 |
| Predicted mean, model 1 |
5.91 |
6.00 |
6.05 |
6.12 |
6.24 |
0.078 (−0.001 to 0.156) |
0.05 |
| Predicted mean, model 2 |
5.94 |
6.03 |
6.08 |
6.15 |
6.25 |
0.079 (0.00 to 0.158) |
0.05 |
| Predicted mean, model 3 | 5.98 | 6.03 | 6.07 | 6.12 | 6.20 | 0.058 (−0.039 to 0.155) | 0.24 |
Definition of abbreviation: CI = confidence interval.
*
Model 1 adjusted for age, sex, race and ethnicity, and cohort.
†
Model 2 adjusted for variables in model 1 in addition to smoking status, and pack-years.
‡
Model 3 adjusted for variables in model 2 in addition to educational attainment, body mass index, height, weight, diabetes mellitus, hypertension, oxygen saturation, white blood cell count, sleep apnea, high-density lipoprotein, statin use, and high milliamperes.