TABLE 2.

PHARMACOKINETIC PARAMETER VALUES FOR LEVOFLOXACIN AND MOXIFLOXACIN IN MICE AFTER SINGLE-DOSE ORAL ADMINISTRATION AND IN PATIENTS WITH TUBERCULOSIS

Drug	Mice*			Humans†
	Dose (mg/kg)	Cmax (μg/ml)	AUC0–∞ (μg⋅h/ml)	Dose (mg)	Cmax (μg/ml)	AUC0–∞ (μg⋅h/ml)
Levofloxacin	200	38.8	107.4
	300	44.6	142.6	1,000	11.6	137
	400	48.5	148.9
Moxifloxacin	100	14.2	23.6	400	5.9	58

Definition of abbreviations: C_max = peak serum concentration; AUC_0–∞ = area under the serum concentration–time curve from time zero to infinity.

^*Mean values from present study (levofloxacin) and from Reference 30 (moxifloxacin).

^†Median values from Reference 32.