TABLE 3.

ODDS OF HIGH PERSISTENT TUMOR NECROSIS FACTOR-α^* IN EARLY LIFE BEFORE AND AFTER ADJUSTMENT FOR CANDIDATE MATERNAL INFLUENCES

Maternal Influences	Unadjusted OR (95% CI)†	P Value	Adjusted OR (95% CI)‡	P Value
Maternal pregnancy weight gain
Low/mid tertiles	Reference		Reference
High tertile	3.4 (1.4–8.2)	0.008	3.2 (1.3–7.9)	0.012
Maternal prepregnant body mass index
Low tertile	Reference		Reference
Mid tertile	1.5 (0.5–4.5)	0.47	1.4 (0.4–4.3)	0.57
High tertile	1.3 (0.4–4.0)	0.64	1.4 (0.5–4.5)	0.54
Maternal asthma and/or rhinitis
No	Reference		Reference
Yes	1.8 (0.8–4.4)	0.17	1.7 (0.7–4.3)	0.23

Definition of abbreviations: CI = confidence interval; OR = odds ratio.

^*Persistent tumor necrosis factor-α as outcome is in the model as the high/high (cord/3 mo) group versus all other.

^†Population for marginal (univariate) analysis (n = 195) is limited to those with data for maternal pregnancy weight gain, prepregnant body mass index, and maternal asthma and/or rhinitis.

^‡Multivariable analysis model applied after determining other maternal factors (age, ethnicity, previous births) and parental smoking and child sex were without independent effects.