TABLE 4.
ODDS OF CHILDHOOD ASTHMA BY CANDIDATE MATERNAL RISK FACTORS
| Maternal Factors | Unadjusted OR (95% CI)* | P Value | Adjusted OR (95% CI)† | P Value |
|---|---|---|---|---|
| Maternal pregnancy weight gain |
|
|
|
|
| Low 2 tertiles |
Reference |
|
Reference |
|
| High tertile |
3.4 (1.7–6.9) |
0.001 |
3.4 (1.6–7.2) |
0.002 |
| Maternal prepregnant body mass index |
|
|
|
|
| Low tertile |
Reference |
|
Reference |
|
| Mid tertile |
0.6 (0.3–1.4) |
0.32 |
0.5 (0.2–1.3) |
0.16 |
| High tertile |
0.4 (0.2–1.0) |
0.057 |
0.4 (0.2–1.1) |
0.072 |
| Maternal asthma and/or rhinitis |
|
|
|
|
| No |
Reference |
|
Reference |
|
| Yes | 3.3 (1.6–6.8) | 0.001 | 2.9 (1.4–6.2) | 0.004 |
Definition of abbreviations: CI = confidence interval; OR = odds ratio.
*
Population for marginal analysis (n = 225) is limited to those with data for pregnancy weight gain, prepregnancy body mass index, and maternal asthma and/or rhinitis.
†
Multivariable analysis model applied after determining other maternal factors (age, ethnicity, previous births), parental smoking, and child sex were without independent effects.