TABLE 5.

ODDS FOR CHILDHOOD ASTHMA WITH MATERNAL PREGNANCY WEIGHT GAIN AND EARLY-LIFE TNF-α PRODUCTION IN THE MODEL

	Unadjusted OR* (95% CI)	P	Adjusted OR† (95% CI)	P
Cord/3 mo TNF-α
All other	Reference		Reference
High/high	3.8 (1.5–9.8)	0.005	3.1 (1.2–8.2)	0.020
Maternal pregnancy weight gain
Low 2 tertiles	Reference		Reference
High tertile	3.1 (1.4–7.0)	0.006	2.7 (1.2–6.1)	0.021

Definition of abbreviations: CI = confidence interval; OR = odds ratio; TNF = tumor necrosis factor.

^*Population for marginal analysis (n = 191) is limited to those with data for early-life TNF-α values and maternal weight gain.

^†Multivariable analysis model applied after determining other maternal factors (age, ethnicity, previous births), parental smoking, and child sex were without independent effects.