. 2013 Jul 1;188(1):77–82. doi: 10.1164/rccm.201212-2199OC

TABLE 2.

LOGISTIC REGRESSION MODELS OF HOSPITAL MORTALITY

		Trivariate Model		Final Multivariate Model
Variable	Value	OR (95% CI)	P Value	OR (95% CI)	P Value
Age^*	Per year	1.03 (1.02–1.03)	<0.0001	1.03 (1.03–1.04)	<0.0001
Acute Physiology Score^†	Per point	1.11 (1.10–1.12)	<0.0001	1.12 (1.11–1.14)	<0.0001
Charlson Comorbidity Index Score^†	Per point	1.06 (1.04–1.09)	<0.0001	1.05 (1.02–1.08)	<0.001
Inotropes and packed red blood cells^*	Compliant^‡	Referent
Inotropes and packed red blood cells^*	Noncompliant^‡	2.31 (1.72–3.11)	<0.0001	1.62 (1.12–2.33)	<0.01
Glucocorticoids^*	Compliant^‡	Referent
Glucocorticoids^*	Noncompliant^‡	2.06 (1.62–2.62)	<0.0001	1.76 (1.32–2.37)	<0.001
Use of low tidal volume ventilation, if mechanically ventilated^*	Compliant^‡	Referent
	Noncompliant^‡	2.77 (1.98–3.87)	<0.0001	1.84 (1.24–2.73)	<0.01
Sex	Male	Referent
Sex	Female	1.00 (0.84–1.21)	0.97
Severity of sepsis^*	Severe sepsis	Referent
Severity of sepsis^*	Septic shock	2.08 (1.71–2.53)	<0.0001
Serum lactate measured^*	Compliant^‡	Referent
Serum lactate measured^*	Noncompliant^‡	1.22 (0.92–1.61)	0.17
Blood cultures before antibiotics^*	Compliant^‡	Referent
Blood cultures before antibiotics^*	Noncompliant^‡	1.55 (1.14–2.11)	<0.01
Broad-spectrum antibiotics^*	Compliant^‡	Referent
Broad-spectrum antibiotics^*	Noncompliant^‡	1.26 (0.97–1.65)	0.09
Fluid resuscitation^*	Compliant^‡	Referent
Fluid resuscitation^*	Noncompliant^‡	1.27 (0.86–1.89)	0.23
Vasopressors	Compliant^‡	Referent
Vasopressors	Noncompliant^‡	0.94 (0.63–1.41)	0.77
Central venous pressure and ScvO₂^*	Compliant^‡	Referent
Central venous pressure and ScvO₂^*	Noncompliant^‡	1.71 (1.32–2.19)	<0.0001
Glucose control^*	Compliant^‡	Referent
Glucose control^*	Noncompliant^‡	1.38 (1.08–1.76)	<0.01
Glucocorticoids^*	Compliant^‡	Referent
Glucocorticoids^*	Noncompliant^‡	2.06 (1.62–2.62)	<0.0001	1.76 (1.32–2.37)	<0.001
Drotrecogin alfa eligibility assessed^*	Compliant^‡	Referent
Drotrecogin alfa eligibility assessed^*	Noncompliant^‡	2.56 (1.87–3.49)	<0.0001
Use of low tidal volume ventilation, if mechanically ventilated^*	Compliant^‡	Referent
	Noncompliant^‡	2.77 (1.98–3.87)	<0.0001	1.84 (1.24–2.73)	<0.01
Total resuscitation bundle	Compliant^§	Referent
Total resuscitation bundle	Noncompliant^§	1.46 (1.21–1.76)	<0.0001
Total maintenance bundle	Compliant^§	Referent
Total maintenance bundle	Noncompliant^§	1.80 (1.42–2.18)	<0.0001
Total bundle	Compliant^§	Referent
Total bundle	Noncompliant^§	1.48 (1.22–1.79)	<0.0001

Definition of abbreviations: CI = confidence interval; ED = emergency department; OR = odds ratio; ScvO₂ = central venous oxygen saturation.

Potential predictors for the final model (P < 0.25 on trivariate analysis).

^{^†}

Covariates for trivariate and multivariate models.

^{^‡}

Compliant = eligible and compliant or ineligible for that single bundle element. Noncompliant = eligible and noncompliant for that single bundle element.

^{^§}

Compliant = eligible and compliant or ineligible for all elements in that bundle. Noncompliant = eligible and noncompliant for any one element in that bundle.