Table 4.
Pressure (MPa) | Mean diameter (nm) | PDI | EE (%) | DLE (%) |
---|---|---|---|---|
0.6 | 339.1 ± 5.1 | 0.137 ± 0.051 | 62.0 ± 6.8 | 40.4 ± 2.9 |
1.0 | 306.8 ± 5.5 | 0.098 ± 0.064 | 81.8 ± 4.5 | 48.4 ± 3.3 |
1.2 | 257.8 ± 3.6 | 0.012 ± 0.031 | 71.9 ± 8.5 | 28.8 ± 3.3 |
Notes: The concentration of polymer in the organic phase was 15 mg/mL and volumetric ratio of organic to aqueous phase was 1:15 with 5% drug loading, the concentration of PVA was 0.5%, and the membrane-pore size was 1.0 μm in three cycles.
Abbreviations: PLA-TPGS, poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate; DTX, docetaxel; PVA, polyvinyl alcohol; PDI, polydispersity index; EE, encapsulation efficiency; DLE, drug-loading efficiency.