Table 4.

Effects of the transmembrane pressure in fabricating DTX-loaded PLA-TPGS nanoparticles on size, PDI, EE, and DLE

Pressure (MPa)	Mean diameter (nm)	PDI	EE (%)	DLE (%)
0.6	339.1 ± 5.1	0.137 ± 0.051	62.0 ± 6.8	40.4 ± 2.9
1.0	306.8 ± 5.5	0.098 ± 0.064	81.8 ± 4.5	48.4 ± 3.3
1.2	257.8 ± 3.6	0.012 ± 0.031	71.9 ± 8.5	28.8 ± 3.3

Notes: The concentration of polymer in the organic phase was 15 mg/mL and volumetric ratio of organic to aqueous phase was 1:15 with 5% drug loading, the concentration of PVA was 0.5%, and the membrane-pore size was 1.0 μm in three cycles.

Abbreviations: PLA-TPGS, poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate; DTX, docetaxel; PVA, polyvinyl alcohol; PDI, polydispersity index; EE, encapsulation efficiency; DLE, drug-loading efficiency.