Table 3. The response rates for varicocelectomy in each genotype and in combination subgroups of GSTM1/T1 and GSTT1/NQO1 genotypes.
| Response rate | P-value | Odds ratio (95% CI) | |
|---|---|---|---|
| Genotype | |||
| Over all | 50.0% (36/72) | ||
| GSTM1 | |||
| null | 51.1% (23/45) | NS | NS |
| wt | 48.1% (13/27) | ||
| GSTT1 | |||
| null | 35.3% (12/34) | 0.018 | 3.14(1.20–8.24) |
| wt | 63.2% (24/38) | ||
| MnSOD | |||
| Ala/Ala+Ala/Val | 61.5% (8/13) | NS | NS |
| Val/Va | 47.5% (28/59) | ||
| NQO1 | |||
| Pro/Pro+Pro/Ser | 45.2% (28/62) | 0.041 | NS |
| Ser/Ser | 80.0% (8/10) | ||
| Combination groups | |||
| GSTT1-wt/GSTM1-wt | 66.7% (8/12) | ||
| GSTT1-null/GSTM1-wt and GSTT1-wt/GSTM1-null | 51.2% (21/41) | NS | NS |
| GSTT1 -null/GSTM1 -null | 36.8% (7/19) | ||
| GSTT1-wt/NQO1-Ser/Ser | 88.9% (8/9) | ||
| GSTT1-null/NQO1-Ser/Ser and GSTT1-wt/NQO1-Pro/Pro or -Pro/Ser | 53.3% (16/30) | NS | NS |
| GSTT 1-null/NQO1-Pro/Pro or -Pro/Ser | 36.4% (12/33) | ||
Abbreviations: Ala, alanine; CI, confidence interval; GSTM1, glutathione S-transferase M1; GSTT1, glutathione S-transferase T1; NQO1, NAD(P)H:quinone oxidoreductase; NS, not significant; Pro, proline; Ser, serine; Val, valine.