. 2009 Jan 26;11(3):385–392. doi: 10.1038/aja.2008.34

Table 2. Effects of D-004 (320 mg day⁻¹) on oxidative variables in healthy men.

Treatment	Baseline	6 weeks	Percent changes
TBARS (MDA μmol mL⁻¹) (mean ± SD)
Placebo	0.42 ± 0.14	0.40 ± 0.11	−4.8
D-004	0.45 ± 0.14	0.33 ± 0.11***,+	−26.7++++
Total hydroxyperoxides (nmol mg⁻¹ prot) (mean ± SD)
Placebo	49.67 ± 17.58	50.04 ± 16.74	+0.7
D-004	56.98 ± 23.18	46.28 ± 17.45***,+	−18.8++++
Sulphydryl groups (mmol mg⁻¹ prot) (mean ± SD)
Placebo	0.71 ± 0.09	0.66 ± 0.19	−7.0
D-004	0.76 ± 0.16	0.52 ± 0.05***,+++	−31.6++++
TAS (mmol L⁻¹) (mean ± SD)
Placebo	0.56 ± 0.14	0.58 ± 0.16	+3.6
D-004	0.51 ± 0.13	0.69 ± 0.14***,+	+35.3+++

Abbreviations: MDA, malondialdehyde; TAS, total antioxidant status; TBARS, thiobarbituric acid-reactive substances;

^**

P < 0.01;

^***

P < 0.001 (compared with baseline [Wilcoxon test for matched samples]).

⁺

P < 0.05;

⁺⁺⁺

P < 0.001;

⁺⁺⁺⁺

P < 0.0001 (compared with placebo [Mann-Whitney U-test]).

Values were means of triplicates.

Table 2. Effects of D-004 (320 mg day−1) on oxidative variables in healthy men.