Table 1.
| PAP | ||||||
|---|---|---|---|---|---|---|
| Pre-Immunization (Net DTH, 10−4 in.) | Post-Immunization (Net DTH, 10−4 in.) | |||||
| Subject ID | +IgG* | +α-CTLA-4* | CTLA-4-Regulated PAP Response |
+IgG* | +α-CTLA-4* | CTLA-4-Regulated PAP Response |
| 02 | 10 ± 0.0 | 15 ± 5.8 | 5 | 10 | 35 | 25† |
| 03 | 30 | 20 | −10 | 30 | 26.7 ± 5.8 | −3.3 |
| 04 | 12.5 ± 5 | 25 ± 10 | 12.5† | 15 ± 5.8 | 13.3 ± 2.9 | −1.7 |
| 05 | 11.25 ± 2.5 | 12.5 ± 5 | 1.25 | 8.3 ± 5.8 | 16.7 ± 5.8 | 8.4† |
| 06 | 20 ± 0 | 22.5 ± 5 | 2.5 | 18.3 ± 2.9 | 45 ± 8.7 | 36.7† |
| 07 | 5 | 10 | 5 | 10 | 50 | 40† |
| 08 | 25 | 25 | 0 | 25 | 20 | −5 |
| 09 | 30 | 40 | 10 | 35 | 35 | 0 |
| 10 | 26.7 ± 5.8 | 27.5 | 0.8 | 20 | 15 | −5 |
| 11 | 10 | 10 | 0 | 0 | 5 | 5 |
| 12 | 10 | 20 | 10 | 5 | 0 | −5 |
| 13 | 30 | 30 | 0 | 30 | 20 | −10 |
| 14 | 10 ± 0 | 16.7 ± 5.8 | 6.7 | 10 ± 0 | 26.7 ± 2.9 | 16.7† |
| 15 | 20 ± 0 | 17.5 | −2.5 | 27.5 | 10 | −17.5 |
| 16 | 10 ± 0 | 10 ± 0 | 0 | 5 ± 5 | 30 ± 0 | 25† |
| 17 | 10 | 10 | 0 | 5 | 20 | 15† |
| 18 | 20 | 20 ± 0 | 0 | 5 | 15 | 10 |
| 19 | 20 | 20 | 0 | 20 | 30 | 10 |
| 20 | 30 | 40 | 10 | 5 | 15 | 10 |
| 21 | 20 | 20 | 0 | 10 | 0 | −10 |
| 22 | 8 ± 4.5 | 10 ± 5 | 2 | 8.75 ± 2.5 | 26.7 ± 7.6 | 17.95† |
†
Indicates CTLA-4-regulated PAP response >15in−4 in at least one assay
*
Shown are the mean ± standard deviation values calculated from triplicate assays. When sample availability precluded triplicate experimental assays, shown is the average experimental values.