Table 2.

Association of the KRAS-variant with specific characteristics of BRCA1 families

Family characteristic	Frequency of the GG+TG genotype	OR	95% CI	P value
No OvC in family	38/152 (25.0%)
One or more OvC in family	22/96 (22.9%)	0.89	0.49–1.63	0.71
No Bil BrC in family	36/147 (24.5%)
One or more Bil BrC in family	24/106 (22.6%)	0.90	0.50–1.63	0.73
Less than 3 BrC < 60 years in family	29/142 (20.4%)
Three or more BrC < 60 years in family	31/111 (27.9%)	1.51	0.84–2.70	0.16

Association of the KRAS-variant with specific characteristics of BRCA1 families was tested for significance by a χ²-test. Case–control odds ratios and their confidence intervals were calculated using Woolf approximations

OvC ovarian cancer, Bil bilateral, BrC breast cancer