Table 1.
Donor | #1 | #2 | #3 | #4 | #5 | #6 |
---|---|---|---|---|---|---|
Age (years) |
53 |
32 |
50 |
20 |
45 |
36 |
Sex |
Female |
Female |
Female |
Male |
Male |
Male |
Medical history |
|
|
|
|
|
|
Brain death cause |
Intra-axial hemorrhage |
Head injury |
Subarachnoid hemorrhage |
Cardiac arrest (37 min) |
Head injury |
Subarachnoid hemorrhage |
Smoking |
Yes |
Yes |
Yes |
Yes |
Yes |
Yes |
Intensive Care Unit data |
|
|
|
|
|
|
Troponin T (μg/L) |
0.1 |
0.01 |
0.01 |
15* |
152* |
1073* |
Central Venous Pressure (mmHg) |
16* |
- |
7 |
- |
13* |
15* |
Length of stay before death (days) |
5 |
1 |
1 |
- |
2 |
3 |
Noradrenaline (μg/kg/min) |
0.6* Dopamine 10 |
0.28* |
0.02 |
0.1 |
- |
0.14* + dobutamine 2.8 |
RESTING Echo |
Apical Hypokinesia* |
Anterior-septal Hypokinesia* |
Apical Akinesia* |
Mild LVEF reduction* |
Septal Hypokinesia* |
Lateral inferior Hypokinesia* |
LVEF, rest (%) |
51* |
46* |
55 |
49* |
60 |
47* |
LV mass index (g/m2) |
145* |
89 |
112* |
89 |
133* |
102 |
WMSI, rest |
1.29* |
1.59* |
1.65* |
1 |
1.18* |
1.26* |
Stress echo |
|
|
|
|
|
|
Dipyridamole infusion (min) |
6 |
6 |
4* |
6 |
6 |
6 |
LVEF, peak (%) |
60 |
56 |
59 |
60 |
75 |
55 |
WMSI, peak |
1.12* |
1.41* |
1.71* |
1 |
1 |
1.11* |
Δ WMSI |
- 0.17 |
- 0.18 |
+ 0.06* |
0 |
- 0.18 |
- 0.15 |
ΔESP/ESVi (mmHg/mL/m2) |
Negative* (- 0.21) |
Flat* (0.08) |
Negative* (-1.7) |
Positive (+0.94) |
Positive (+1.2) |
Flat (0) |
Autopsy findings |
Mild DCM* |
- |
CAD, 90% LAD coronary stenosis* |
- |
- |
- |
Histology |
Replacing interstitial fibrosis |
- |
Coagulative necrosis, colliquative myocytolysis |
- |
- |
- |
Heart TX |
- |
- |
- |
YES |
YES |
YES |
Cold ischemia time (min) |
|
|
|
180 |
172 |
150 |
Recipient |
|
|
|
|
|
|
Age/sex |
|
|
|
56/M |
48/M |
55/M |
Disease |
|
|
|
Ischemic DC |
Congenital HD |
HCM |
UNOS Status |
|
|
|
2 |
2 |
2 |
Post-TX angiography |
|
|
|
Normal |
Normal |
Normal |
Intravascular Ultrasound-intimal thickness |
|
|
|
- |
LAD focal |
0.6 mm LAD |
Month 1 LVEF (%) |
|
|
|
50 |
62 |
58 |
Post TX endomyocardial biopsies |
|
|
|
regular myocardium |
isolated foci of ischemic per transplant injury |
regular myocardium |
Follow-up months | 26 alive | 9 alive | 12 alive |
*Not Normal.