Figure 9.

Rho signaling in the maintenance of amoeboid morphology and invasion/metastasis of sarcoma cells. The activation of Rho, ROCK and the phosphorylation of MLC are all crucial for the effective invasiveness/metastasis of amoeboid sarcoma cells. In contrast, the rounded morphology of amoeboid sarcoma cells is not dependent on MLC phosphorylation or non-muscle myosin II ATPase activity, suggesting another downstream effectors of Rho/ROCK pathway are involved in the maintenance of rounded morphology of cancer cells.