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. 2013 Jul 2;105(15):1111–1122. doi: 10.1093/jnci/djt153

Figure 1.

Figure 1.

Withaferin A (WA) administration decreases burden of macroscopic (tumor size) and microscopic tumors (tumor area) in mouse mammary tumor virus–neu (MMTV-neu) transgenic mice. A) Chemical structure of WA. B) Representative hematoxylin and eosin–stained sections of mammary glands showing ductal carcinoma in situ (DCIS), papillary tumor, and focus of invasive carcinoma around papillary tumor (×50 magnification, scale bars = 400 µm). C) Overall tumor incidence in MMTV-neu mice of the WA treatment group and the control group. The P value was calculated by two-sided Fisher exact test. D) Macroscopic tumor burden. Results represent the mean weight of palpable tumors (macroscopic tumors) with a cutoff of ≥.05g with corresponding 95% confidence intervals (error bars). Statistical significance of differences was determined by two-sided Student t test. E) Microscopic tumor burden (area) of DCIS plus papillary tumors and invasive carcinoma lesions. Results represent the mean areas of DCIS plus papillary tumors and invasive carcinoma with their corresponding 95% confidence intervals (error bars). Statistical significance of differences was determined by two-sided Student t test.