Figure 9. Adoptive transfer of IL-10-deficient CD11c⁺ cells failed to restore the renoprotective effect of the MSCs.

The CD11c⁺ cells were isolated from the WT and IL-10 KO mice and adoptively transferred into the CD11c⁺-DTR transgenic mice after DT (4 ng/g) injection (1 × 10⁶ cells). One million MSCs were then intraperitoneally administered 4 h before renal I/R and the mice were then sacrificed and (A) the serum creatinine levels, (B) the tubular injury and (C) the mean numbers of apoptotic cells per HPF were measured at 24 h after renal I/R injury (n = 4–5 per group). * p < 0.05 compared to sham, ** p < 0.05 compared to MSC + I/R in the CD11c-DTR transgenic mice.