Table 4. Univariate Cox regression analysis of dichotomized and continuous AQUA scores for OS.

	Dichotomized AQUA Scores			Continuous AQUA Scores*
Marker	Hazard Ratio	95% CI	P value	Hazard Ratio	95% CI	P value
B-Raf	0.89	0.66–1.19	0.4175	0.99	0.90–1.09	0.8185
c-Kit	0.77	0.59–1.02	0.0728	0.89	0.80–1.00	0.0410
C-Raf	0.93	0.70–1.23	0.5961	0.91	0.80–1.03	0.1470
FGF-R1	0.75	0.57–0.98	0.0381	0.86	0.79–0.93	0.0004
VEGF-R1	0.75	0.56–1.00	0.0517	0.88	0.80–0.97	0.0120
VEGF-R3	1.03	0.78–1.36	0.8274	0.98	0.91–1.06	0.6869
MEK1	0.94	0.71–1.26	0.6883	0.96	0.87–1.05	0.3228
PDGF-Rβ	0.81	0.61–1.07	0.1421	0.92	0.83–1.02	0.1079
STMN1	1.09	0.80–1.48	0.5927	1.01	0.93–1.09	0.8337
MAP2	0.83	0.61–1.13	0.2359	0.95	0.88–1.03	0.1956
EB1	0.83	0.63–1.10	0.2028	0.97	0.90–1.05	0.4323
Bcl-2	1.05	0.80–1.39	0.7192	1.00	0.93–1.08	0.9552
ERK1/2	0.96	0.71–1.28	0.7564	0.95	0.88–1.03	0.2056
VEGF-R2	1.06	0.80–1.39	0.7012	0.95	0.83–1.08	0.4140

*Hazard ratios were calculated per 10-point change in AQUA scores.