Figure 1. Efficiency (kcat/Km, 1/nM⋅sec) of the DNA endonuclease cleavage of the AP-DNA strand by hAPE1.

Empty and shaded columns designate the values obtained in the presence of Mg²⁺ and Mn²⁺ ions, respectively. The results are presented as the average value of four independent experiments. Standard error was estimated as 10%.