Figure 2. Influence of hXRCC1 on the endonuclease activity of hAPE1 (A), and on the incorporation of dNMP catalyzed by DNA polymerases beta (B) and lambda (C).

The data are presented in logarithmic scale. Solid lines designate the yield of the reaction products obtained in the presence of Mg²⁺ ions; dotted lines designate the yield of the reaction products obtained in the presence of Mn²⁺ ions. The yield of the reaction products is the ratio of the reaction products over the initial amount of substrate expressed as a percentage. dGTP was used for the reactions with DNA1 and DNA3, and dATP – for the reactions with DNA2 and DNA4. The results are presented as the average value of four independent experiments. Standard error was estimated as 10%.