Table 1. Disulfide bond formation in P2X receptors.
Clone | Inter or intra | Effects | Subtype | Reference |
K68C/F291C | Inter-subunit | ATP binding site in P2XRs | rP2X1R | [48], [49] |
H120C/H213C | Inter-subunit | Inter-subunit Zn2+ binding site | rP2X2R | [50] |
E167C/R290C | Inter-subunit | The distance between these two residues is less than 4.6 Å | rP2X2R | [51] |
E59C/Q321C | Inter-subunit | Lateral fenestrations become larger when the channel opens | rP2X2R | [52] |
E63C/R274C | Inter-subunit | ATP triggers relative movement of adjacent subunits head to tail | rP2X2R | [38] |
V48C/I328C | Inter-subunit | Orientation of P2XR subunits; outward motion of each subunit | rP2X2R | [21] |
K190C/N284C G60C/D320C I62C/L318C P196C/D320C P196C/K322C R197C/K322C F188C/N284C | Inter-subunit | ATP triggers relative movement of adjacent subunits | hP2X1R | [53] |