Table 2.
Relation of MATH to Overall Survival
| Relation to Overall Survival | |||||
|---|---|---|---|---|---|
| Analysis | deaths/ cases |
Hazard Ratio |
95% CI | p-value | |
| Univariate | 39/74 | 1.047/unit | (1.017 - 1.078) | 0.002 | |
| primary tumors | 34/67 | 1.044/unit | (1.013 - 1.075) | 0.005 | |
| Stratified by recurrence | 39/74 | 1.046/unit | (1.015 - 1.077) | 0.003 | |
| Stratified by HPV status | 39/73 | 1.051/unit | (1.018 - 1.084) | 0.002 | |
| primary tumors | 34/66 | 1.046/unit | (1.013 - 1.081) | 0.006 | |
| Univariate; HPV-negative subset | 35/62 | 1.050/unit | (1.017 - 1.083) | 0.003 | |
| primary tumors | 30/55 | 1.045/unit | (1.012 - 1.080) | 0.008 | |
| Stratified by TP53 mutation status | 39/74 | 1.048/unit | (1.016 - 1.080) | 0.003 | |
| primary tumors | 34/67 | 1.046/unit | (1.014 - 1.079) | 0.005 | |
| Univariate; disruptive TP53 subset | 15/30 | 1.088/unit | (1.031 - 1.15) | 0.002 | |
| primary tumors | 14/29 | 1.094/unit | (1.033 - 1.16) | 0.002 | |
| Stratified by PNI status | 36/67 | 1.035/unit | (1.002 - 1.068) | 0.035 | |
| primary tumors | 31/60 | 1.030/unit | (0.997 - 1.064) | 0.078 | |
| Univariate; subset with PNI | 25/36 | 1.047/unit | (1.006 - 1.089) | 0.023 | |
| primary tumors | 21/31 | 1.041/unit | (0.999 - 1.084) | 0.055 | |
| Stratified by T classification (1,2 vs. 3,4) | 36/70 | 1.043/unit | (1.012 - 1.075) | 0.006 | |
| primary tumors | 34/67 | 1.042/unit | (1.010 - 1.075) | 0.009 | |
| Univariate, subset with T > 2 | 25/46 | 1.049/unit | (1.011 - 1.088) | 0.011 | |
| primary tumors | 24/44 | 1.047/unit | (1.008 - 1.086) | 0.016 | |
| Stratified by Stage (II,III vs IV) | 36/70 | 1.047/unit | (1.015 - 1.081) | 0.004 | |
| primary tumors | 34/67 | 1.047/unit | (1.014 - 1.082) | 0.006 | |
| Univariate; subset with Stage IV | 29/52 | 1.059/unit | (1.020 - 1.10) | 0.003 | |
| primary tumors | 28/50 | 1.057/unit | (1.018 - 1.098) | 0.004 | |
| Stratified by N classification (0,1 vs. 2,3) | 36/70 | 1.048/unit | (1.016 - 1.080) | 0.003 | |
| primary tumors | 34/67 | 1.049/unit | (1.017 - 1.083) | 0.003 | |
| Univariate; subset with N > 1 (all primary) | 25/36 | 1.056/unit | (1.016 - 1.096) | 0.005 | |
| Multivariate (based on variables significantly related to outcome in univariate analyses) |
33/63 | 4 × 10−6 | |||
| MATH | 1.043/unit | (1.008 - 1.080) | 0.017 | ||
| Age | 0.946/yr | (0.910 - 0.982) | 0.003 | ||
| N >1 | 4.92§ | (2.18 - 11.1) | 0.0001 | ||
| PNI | 2.49 | (1.15 - 5.39) | 0.021 | ||
| Multivariate | primary tumors | 31/60 | 4 × 10−6 | ||
| MATH | 1.045/unit | (1.008 - 1.084) | 0.016 | ||
| Age | 0.940/yr | (0.904 - 0.978) | 0.002 | ||
| N >1 | 5.94 | (2.45 - 14.4) | 0.0001 | ||
| PNI | 2.48 | (1.11 - 5.53) | 0.027 | ||
| Univariate; cases not involving chemotherapy | 13/30 | 1.00/unit | (0.945 - 1.062) | 0.96 | |
| primary tumors | 9/24 | 0.989/unit | (0.924 - 1.059) | 0.74 | |
| Univariate; cases involving chemotherapy (all primary) | 23/41 | 1.061/unit | (1.022 - 1.10) | 0.002 | |
Results of Cox proportional hazards analysis on relations of MATH to overall survival of patients with tumor exome sequencing results reported by Stransky et al.25 Each analysis was performed on all cases having values for the variable(s) of interest, and on the subsets involving primary tumors, with the number of cases and of deaths shown. Hazard ratios are for MATH unless otherwise noted. MATH and Age were analyzed as continuous variables, so results for those variables are reported as multiplicative change in hazard per unit increase in MATH value or per year of age.
Evidence of non-proportional hazards for N; p = 0.048 in chi-square test for trend of coefficient of N with time. Relations of the other 3 variables to overall survival were similar in analysis stratified by N to allow for this non-proportionality; in that stratified analysis, global chi-square test had p = 0.96.