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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: J Immunol. 2013 Jul 3;191(4):1606–1613. doi: 10.4049/jimmunol.1301116

Figure 1. Inhibition of Notch signaling in myelin-reactive CD4+ T cells markedly attenuates EAE.

Figure 1

(A) Experimental design; (B) Mean clinical EAE score (≥2 experiments); (C) Percent disease incidence (score ≥2) of immunized wild-type (WT), DNMAML (DN) or CSL/RBP-Jk-deficient (RBKO) mice (pooled results from ≥2 experiments for each strain). In all models, Cd4-Cre-mediated Notch inactivation was achieved specifically in mature T cells; (D) Mean clinical score in TCR transgenic 2D2 or 2D2/DN mice (expressing DNMAML in T cells) (≥3 experiments); (E) Percent disease incidence (score ≥2) of immunized 2D2 and 2D2/DN mice (≥2 experiments); (F) Luxol fast blue and (G) H&E staining of spinal cord lumbar sections from 2D2 and 2D2/DN mice (representative of n=3 mice/group; 2 experiments); (H) Number of white matter infiltrates per H&E section (counted blindly). p<0.01**.