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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: J Immunol. 2013 Jul 8;191(4):1724–1731. doi: 10.4049/jimmunol.1300921

Figure 6. Induction of in vivo tolerance with STALs displaying 3’-BPANeuGc.

Figure 6

(A,B) Robust tolerance to A, T-independent (NP, n=4) and B, T-dependent antigen (HEL, n=8) in Siglec-G dependent manner. C, STALs displaying a natural α2-3-sialoside (3’-NeuGc) also induce tolerance to NP in a Siglec-G dependent manner (n=4). In all studies, mice were injected at day 0 with either liposomes displaying antigen alone or liposomes displaying antigen and Siglec-G ligand. On day 14 and 28 all mice received a challenge with liposomes displaying antigen alone. Antibody titers were assessed by ELISA. Data represents mean ± s.e.m.