Table 1.
Volunteer demographics
| Subject (Case) |
Category | Sex | MMSE | CERAD-I | CERAD-D | CERAD-R | Flow Asymmetry (voxels) |
Cortical Volume / ICV |
VBA-CBF | RICA-CBF | LICA- CBF |
WML |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 (6) | Control | F | 30 | 22 | 9 | 10 | 41714 | 0.449 | 50 | 54 | 58 | 4 |
| 2 (8) | Control | F | 30 | 28 | 10 | 10 | 65696 | 0.403 | 38 | 44 | 49 | 12 |
| 3 (10) | Control | F | 30 | 25 | 9 | 10 | 30961 | 0.384 | 51 | 51 | 49 | 52 |
| 4 (11) | Control | F | 30 | 19 | 8 | 10 | 119888 | 0.404 | 47 | 52 | 48 | 16 |
| 5 (12) | Control | M | 30 | 18 | 4 | 9 | 95057 | 0.400 | 39 | 34 | 35 | 7 |
| 6 (13) | Control | F | 29 | 24 | 10 | 10 | 31380 | 0.423 | 46 | 49 | 41 | 13 |
| 7 (20) | Control | F | 30 | 28 | 6 | 10 | 33713 | 0.437 | 37 | 35 | 37 | 7 |
| 8 (24) | Control | M | 29 | 19 | 5 | 10 | 106346 | 0.380 | 34 | 35 | 40 | N/A |
| 9 (7) | At-risk | F | 29 | 21 | 8 | 10 | 85334 | 0.390 | 58 | 42 | 43 | 1 |
| 10 (17) | At-risk | F | 30 | 18 | 6 | 8 | 23124 | 0.451 | 48 | 43 | 44 | 25 |
| 11 (21) | At-risk | F | 29 | 20 | 6 | 10 | 57529 | 0.368 | 32 | 48 | 40 | 53 |
| 12 (22) | At-risk | F | 30 | 25 | 7 | 10 | 24618 | 0.442 | 56 | 56 | 63 | 52 |
| 13 (25) | At-risk | F | 30 | 21 | 6 | 10 | 45335 | 0.400 | 66 | 54 | 59 | 6 |
| 14 (9) | At-risk | M | 29 | 14 | 5 | 10 | 137528 | 0.347 | 39 | 43 | 61 | 40 |
| 15 (19) | At-risk | M | 30 | 18 | 6 | 10 | 42080 | 0.395 | 40 | 39 | 39 | 2 |
| Mean | 29.7 | 21.3 | 7.0 | 9.8 | 62686 | 0.405 | 45.3 | 45.1 | 47.2 | 20.7 | ||
| STD | 0.5 | 4.0 | 1.9 | 0.6 | 37207 | 0.030 | 9.7 | 7.3 | 9.4 | 19.9 | ||
| 16 (14) | MCI | F | 27 | 13 | 2 | 8 | 75142 | 0.313 | 29 | 33 | 39 | 4 |
| 17 (15) | MCI | M | 29 | 16 | 6 | 8 | 56283 | 0.363 | 30 | 34 | 35 | 6 |
| 18 (18) | MCI | M | 27 | 20 | 4 | 10 | 168905 | 0.369 | 28 | 33 | 38 | 11 |
| 19 (23) | MCI | M | 26 | 8 | 2 | 7 | 41574 | 0.360 | 24 | 28 | 26 | 1 |
| 20 (26) | MCI | M | 27 | 17 | 0 | 2 | 66258 | 0.357 | 43 | 37 | 58 | 4 |
| 21 (27) | MCI | M | 27 | 9 | 1 | 10 | 38206 | 0.260 | 61 | 65 | 59 | 45 |
| 22 (28) | MCI | F | 23 | 14 | 0 | 1 | 27758 | 0.338 | 52 | 48 | 48 | 33 |
| Mean | 26.6 | 13.9 | 2.1 | 6.6 | 67732 | 0.337 | 38.1 | 40.0 | 43.4 | 14.6 | ||
| STD | 1.8 | 4.3 | 2.2 | 3.6 | 47571 | 0.039 | 13.9 | 12.7 | 12.2 | 17.3 |
Control: No parent with Alzheimer’s disease and does not possess any copies of the APOE-ε4 allele; At-risk: Either one parent with Alzheimer’s disease or one or two copies of the APOE-ε4 allele; MCI: clinically confirmed mild cognitive impairment (one ore more domain). MMSE: Mini-Mental State Exam (max score = 30); CERAD: Consortium to Establish a Registry for Alzheimer’s Disease immediate (CERAD-I; max score = 30), delayed (CERAD-D; max score = 10) and recognition (CERAD-R; max score = 10) neuropsychological exam. Higher scores denote better performance on the exam. ICV: intracranial volume; CBF: cerebral blood flow; VBA: vertebrobasilar territory; RICA: right internal carotid artery territory; LICA: left internal carotid artery territory; STD: standard deviation.