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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: J Immunol. 2013 Jul 5;191(4):1948–1956. doi: 10.4049/jimmunol.1202092

Figure 4. Anti-CD40L mAb treatment abrogates direct but not indirect T cell alloresponses.

Figure 4

C3H mice were transplanted with a conventional B6 skin allograft and treated with anti-CD40L mAbs (MR1, 0.25 mg given i.p. at d2, 4 and 6 post-transplantation) (solid bars). The frequencies of T cells secreting γIFN following activation through the direct (panel A) or indirect (panel B) allorecognition pathway were tested at d5, d10 and d20 post-transplantation. Control non-transplanted mice (white bars) and non-transplanted mice treated with MR1 (striated bars) as well as mice transplanted but not treated (grey bars) were also tested. The results are expressed as numbers of γIFN-forming spots per million T cells ± SD and are representative of 8-12 mice tested individually in each group.