Table 1. Activation of distinct cellular pathways by lysosome-disrupting agents and pyroptosis inducers.

	Lysosome-destabilizing agents	Pyroptosis inducers
Lysosome rupture precedes cell death	Yes	No
Lysosome-mediated cell death	Yes	No
Degradation of inflammatory proteins	Yes	No
Caspase-1-mediated cell death (pyroptosis)	No	Yes
Nlrp3 signaling	Weak	Strong
IL-1β release	Weak	Strong