Figure 3. KEGG pathway regarding the phosphatidylinositol signaling system and oocyte meiosis. (A) The diacylglycerol (DG or DAG) was produced by phospholipase C (PLC) lysing its substrates: phosphatidylinositol (PI), PI(4)P and PI(4,5)P2. The enzymes promoting the accumulation of these substrates, like PI4K (Pi4k2a), PI5K (Pikfyve), 2.7.1.149 (Pip4k2a, Pip4k2c), were upregulated in SN oocytes (red), whereas enzymes decreasing the PLC substrates like 2.7.1.137 (Pik3r1, Pik3r2, Pik3c3), 2.7.1.154 (Pik3r1, Pik3r2), 2.7.1.153 (Pik3r1, Pik3r2) were downregulated in SN oocytes (green). (B) AC, adenylate cyclase 1 (Adcy1); CPEB, cytoplasmic polyadenylation element binding protein 1 (Cpeb1); p42MAPK, mitogen-activated protein kinase 3 (Mapk3); Cdc20, cell division cycle 20 homolog; 14-3-3, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (Ywhae), β polypeptide (Ywhab); Securin, pituitary tumor-transforming gene 1 (Pttg1); PP2A, protein phosphatase 2, catalytic subunit, β isoform (Ppp2cb); CycE, cyclin E1 (Ccne1); and Calm, calmodulin 1 (Calm1). Upregulated genes in SN oocytes, red; downregulated genes in SN oocytes, green.