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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2013 May 17;62:1–7. doi: 10.1016/j.yjmcc.2013.05.005

Fig. 3.

Fig. 3

Ang II-induced downstream signal transduction was inhibited by adenovirus encoding ADAM17 miRNA. VSMC were infected with adenovirus encoding miCon or miA17-450 at 100 MOI for 3 days and stimulated with 100 nM Ang II for 2 min (A) or 10 min (B). Cell lysates were analyzed by immunoblotting with antibodies as indicated. Representative blots are shown from triplicated experiments. C, Densitometry analysis of the blots from triplicated experiments (mean ± SD, * p <0.05 compared with stimulated control). D, After infection with adenovirus encoding miA17-450 or miCon (100 MOI), VSMCs were stimulated by AngII (100 nM) for 3 days. Cell protein accumulation was measured. Data are mean ± SD of 4 experiments. *p<0.05 compared with stimulated control.