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. Author manuscript; available in PMC: 2014 Jun 21.
Published in final edited form as: ACS Chem Biol. 2013 Mar 29;8(6):1232–1240. doi: 10.1021/cb400027q

Figure 2. Competitive inhibition of EI by αKG.

Figure 2

Michaelis-Menten kinetics for EIC with the substrate PEP. Enzymatic assays were performed in the presence of 0 (red), 2 (blue) and 4 (green) mM αKG. The kinetic data were fitted using competitive (a) and non-competitive (b) inhibition models. (c) Simulation of the percentage of intracellular EI bound to PEP at different concentration of αKG (see Methods).