Table 1.

Comparison between the chemical shift parameters (Δω_N) for the open/closed conformational exchange of EIC obtained by NMR relaxation dispersion experiments (14), and ¹⁵N chemical shift perturbations (Δδ_N) induced by αKG on the NMR spectrum of EIC.

	G337	K340	E341	L355	W357	R358	A359	I426	G427	R465	N467
|ΔωN| (ppm)a	2.0	0.6	1.0	1.1	1.0	0.7	2.0	1.9	2.0	0.8	0.8
ΔδN (ppm)	0.6	0.1	0.4	-	0.7	0.9	1.1	1.6	1.5	1.0	-
|(|ΔωN|-ΔδN)|/|ΔωN|	0.7	0.8	0.6	-	0.3	0.3	0.4	0.2	0.3	0.2	-

^aThe error in the values of |Δω_N| is ±0.1 ppm with the exception of that for Leu³⁵⁵ and Arg⁴⁶⁵ which is ±0.2 ppm.