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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Biomol Screen. 2013 May 2;18(8):930–937. doi: 10.1177/1087057113483559

Fig. 1. The canonical pathway of protein translation from mRNA.

Fig. 1

(a) emphasizing that misfolded proteins are retained in the cell (ER and elsewhere) and can be rescued by target specific pharmacoperone drugs (gray arrow) that correct misfolding and restore function. Redrawn from 5. (b) The previously reported HTS protocol involving multiple wash steps (gray box) and lengthy incubations. (c) The new optimized ultra-HTS compatible no-wash protocol. Changes from the wash protocol are denoted in bold.