Table 5.
ABC transporter gene expression profiles*
| Genes | P11 | P 2 | P 3 | P 7 | P 10 | P 1 | P 5 | P 8 | P 6 | P 4 | P 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| M0 | M1 | M1 | M1 | M2 | M4 | M4 | M4 | M5a | M5b | M5b | |
| ABCA3 | −2.2 | NA | NA | 2.1 | NA | NA | NA | NA | 2.6 | NA | NA |
| ABCB1 | 3.5 | −9.4 | 2.5 | −6.0 | −2.2 | NA | 5.7 | 3.8 | −2.4 | −4.6 | 24.6 |
| ABCB4 | 4.6 | −14.9 | NA | NA | NA | −10.7 | 2.5 | NA | NA | NA | −13.3 |
| ABCC1 | NA | NA | NA | NA | NA | NA | 2.0 | −2.5 | NA | 4.3 | 5.4 |
| ABCC2 | NA | 3.8 | −2.9 | −2.0 | NA | NA | NA | NA | NA | NA | −2.9 |
| ABCC3 | 25.9 | NA | 13.3 | NA | NA | −3.8 | −6.4 | NA | NA | −5.1 | −43.5 |
| ABCC4 | NA | −3.0 | NA | NA | NA | NA | NA | −10.0 | −3.2 | 3.4 | 3.2 |
| ABCC5 | NA | NA | NA | NA | NA | NA | NA | NA | −2.4 | NA | NA |
| ABCG2 | NA | 3.8 | −7.4 | NA | 3.3 | NA | NA | 2.5 | 2.0 | NA | 8.3 |
*
Fold-change of 9 ABC transporters known to be involved in chemotherapy resistance, in samples taken after relapse compared with their counterparts taken at diagnosis
Abbreviations: P = patient; NA = not applicable (no detection of the measured genes)