Table 2.
Naive (n = 10) | KO Pre (n = 6) | KO Post (n = 6) | WT Pre (n = 5) | WT Post (n = 5) | |
---|---|---|---|---|---|
BMS | 9 | 5.7 ± 0.4 | 5.6 ± 0.2 | 4.8 ± 0.2 | 5.0 ± 0.3 |
Trunk displacement (cm) | 0.54 ± 0.04 | 1.01 ± 0.31 | 0.64 ± 0.11 | 1.24 ± 0.40 | 0.87 ± 0.26 |
Toe dragging (s) | 0.031 ± 0.001 | 0.067 ± 0.010 | 0.051 ± 0.004 | 0.077 ± 0.013 | 0.078 ± 0.007 |
Swing time (s) | 0.113 ± 0.005 | 0.060 ± 0.012 | 0.078 ± 0.005 | 0.055 ± 0.023 | 0.068 ± 0.019 |
Stance time (s) | 0.30 ± 0.01 | 0.69 ± 0.09 | 0.52 ± 0.04 | 0.82 ± 0.14 | 0.91 ± 0.09 |
Peak ankle velocity (cm/s) | 22.9 ± 1.5 | 15.5 ± 3.3 | 19.3 ± 1.6 | 11.4 ± 4.7 | 12.3 ± 3.7 |
Peak toe velocity (cm/s) | 30.0 ± 1.8 | 21.8 ± 4.7 | 27.7 ± 2.0 | 16.4 ± 6.8 | 19.6 ± 5.5 |
Gridwalk (% success) | 84.3 ± 1.7 | 12.3 ± 3.2 | 11.3 ± 3.1 | 13.1 ± 1.2 | 14.6 ± 3.0 |
Recovery was examined before (35 d) and after (42 dpi) LTT in KO and WT mice using a battery of locomotor tests. Open field (BMS), gridwalk, and kinematic measures revealed no improvements or deficits that resulted from training in KO and WT groups. Data are shown as means ± SEM.