Fig. 1.

Plasma levels of PL, TC, FC, CE, and TG, and the FC/TC ratio, before, during, and after 6 weeks of repetitive administration of MDCO-216 to cynomolgus monkeys. The values for week 3 or week 6 of drug administration refer to plasma samples taken 1 h prior to the infusion occurring on day 15 or 41, respectively. Since effects on lipids and apoproteins were of similar size in males and females, values for both genders were pooled for calculation of averages and SEM. Week 1; plasma sample taken 7 days before start of first infusion. Week 10: plasma sample taken 70 days after the first infusion and 28 days after last infusion. Data are averages ± SEM of n = 10 (5 males and 5 females) for monkeys receiving vehicle (0) and 300 mg/kg, and n = 6 (3 males and 3 females) for monkeys receiving 30 mg/kg and 100 mg/kg, except on week 10 where data are averages ± SEM for n = 4 (2 males and 2 females). For each monkey and measured parameter, the delta (week X − baseline at week 1) were calculated, with X being 3, 6, or 10 weeks. ANOVA was performed on these delta-values, with treatment dose as independent experimental variable, followed by Dunnett's post-hoc test to see whether deltas in each of the drug-treated groups (30, 100, or 300 mg/kg/occasion) differed significantly (P < 0.05) from the vehicle-treated group. Dots marked with an asterisk indicate significant differences between the drug-treated and vehicle-treated groups (P < 0.05).