Fig. 8.

Cholesterol efflux measured in sera taken at (A) 5 min or (B) 24 h after infusion on day 41, as function of administered dose of MDCO-216. Global, basal, and ABCA1-mediated effluxes were measured in J774 cells, SRB1-mediated efflux in Fu5AH cells, and ABCG1-mediated efflux in BHK cells as described in Materials and Methods. Concentration of serum in the efflux assays was 2% by volume. Data for male and female monkeys were pooled. Bars represent averages ± SEM for n = 10 (vehicle and 300 mg/kg doses) or n = 6 (30 and 100 mg/kg doses) monkeys. Effluxes marked with an asterisk indicate significant differences between the drug-treated and vehicle-treated groups (ANOVA followed by Dunnet's test).