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Time course of plasma lipid responses to atorvastatin for wild-type (WT) versus PCSK9-Y119X mice. A: Study design. B: Plasma LDL-C levels at biweekly intervals over 8 weeks treatment. C: Plasma total cholesterol at intervals over 8 weeks. D: Plasma total bile acids at intervals over 8 weeks. Mean values [n = 10 mice; 6 males (M), 4 females (F)] and 95% confidence intervals are shown.
