TABLE 2.

Liver gene expression with different responses for male versus female mice

	mRNA Concentration by RT-PCR (Normalized to 18S RNA)
Gene	WT (n = 10)	WT + Statin (n = 10)	PCSK9-Y119X (n = 10)	PCSK9-Y119X + Statin (n = 10)
SREBP2
Male	100 ± 10.4	197 ± 23.7	95.1 ± 16.7	199 ± 16.7
Female	157 ± 28.2	326 ± 39.8*	147 ± 20.0	283 ± 13.6*
CYP7A1
Male	100 ± 46.4	257 ± 83.0	88.3 ± 80.7	179 ± 52.0
Female	275 ± 70.1	381 ± 173	138 ± 94.9	337 ± 108
CYP7B1
Male	100 ± 32.3	115 ± 44.4	131 ± 82.6	109 ± 26.1
Female	19.9 ± 2.36	19.5 ± 2.89	24.3 ± 4.77	12.2 ± 1.13
CYP8B1
Male	100 ± 16.4	169 ± 26.3	72.7 ± 17.2	141 ± 19.3
Female	41.9 ± 7.8	160 ± 26.5*	41.5 ± 10.8	171 ± 22.8*

Table lists data for four genes from those summarized in Table 1 which showed significant quantitative differences for female versus male mice. Shown are mean ± SD for n = 6 (male) and n = 4 (female) mice per group. *P < 0.01 versus control for respective genotype. WT, wild type.