. 2013 Sep;54(9):2410–2422. doi: 10.1194/jlr.M038505

TABLE 3.

Kinetic parameters in rat brain total phospholipids and four major phospholipid classes

	k_i* (ml/day/g)		J_in (nmol/g/day)		J_FA (nmol/g/day)		F_FA (%/day)		t_1/2 (day)
	Vehicle	MEP	Vehicle	MEP	Vehicle	MEP	Vehicle	MEP	Vehicle	MEP
Palmitate
Total PL	12 ± 2.9	15 ± 2.8	2,004 ± 468	2,478 ± 458	32,728 ± 17,692	19,285 ± 6,630	127 ± 57	80 ± 30	0.64 ± 0.29	0.95 ± 0.32
ChoGpl	8.0 ± 1.3	10 ± 0.82*	1,297 ± 214	1,649 ± 134*	20,713 ± 9,692	12,720 ± 3,120	84 ± 33	53 ± 13	0.92 ± 0.33	1.4 ± 0.38
EtnGpl	1.9 ± 0.35	2.4 ± 0.4	303 ± 56	393 ± 65	4,926 ± 2,623	3,062 ± 1,011	161 ± 66	110 ± 37	0.49 ± 0.18	0.69 ± 0.24
PtdIns	1.0 ± 0.23	1.9 ± 0.61*	161 ± 38	310 ± 100*	2,679 ± 1,655	2,443 ± 1,153	292 ± 80	311 ± 135	0.25 ± 0.073	0.25 ± 0.098
PtdSer	0.49 ± 0.28	0.65 ± 0.33	80 ± 46	105 ± 54	1,253 ± 792	849 ± 562	356 ± 259	261 ± 194	0.26 ± 0.13	0.39 ± 0.24
DHA
Total PL	28 ± 2.9	25 ± 1.9	17 ± 1.8	16 ± 1.2	7,259 ± 958	4,390 ± 988*	75 ± 7.7	51 ± 10*	0.92 ± 0.089	1.4 ± 0.26
ChoGpl	8.2 ± 0.99	6.9 ± 0.61	5.2 ± 0.62	4.3 ± 0.38	2,146 ± 225	1,234 ± 344*	150 ± 14	90 ± 20*	0.47 ± 0.044	0.79 ± 0.16
EtnGpl	13 ± 2.2	12 ± 1.9	7.9 ± 1.4	7.2 ± 1.2	3,233 ± 184	2,030 ± 492*	55 ± 5.4	37 ± 9.6	1.3 ± 0.13	1.9 ± 0.47
PtdIns	2.8 ± 0.12	2.7 ± 0.48	1.8 ± 0.078	1.7 ± 0.3	688 ± 144	477 ± 106	458 ± 156	308 ± 105	0.16 ± 0.052	0.24 ± 0.081
PtdSer	0.90 ± 0.084	1.1 ± 0.18	0.56 ± 0.053	0.68 ± 0.11	237 ± 50	198 ± 79	9.2 ± 2.1	8.4 ± 3.1	7.6 ± 1.5	9.1 ± 3.7
EPA
Total PL	20 ± 4	26 ± 2.4	5.7 ± 1.1^##	7.3 ± 0.7^!	47 ± 5.7^##	31 ± 4.8*	21 ± 2.9^##	17 ± 2.3	3.3 ± 0.45^#	4.2 ± 0.58
ChoGpl	9.9 ± 1.9	13 ± 1.1^#	2.8 ± 0.55^##	3.7 ± 0.31^!	23 ± 3.3^##	16 ± 2.3*	46 ± 6.9^##	28 ± 4.5*	1.5 ± 0.22^#	2.5 ± 0.47*
EtnGpl	2.7 ± 0.66^#	4.3 ± 0.61*	0.78 ± 0.19^#	1.2 ± 0.17*	6.4 ± 1.3^###	5.4 ± 1.4	8.4 ± 0.81^##	9.5 ± 3.3	8.3 ± 0.8^##	8.4 ± 4.2
PtdIns	1.8 ± 0.3^#	2.5 ± 1.4	0.52 ± 0.087^###	0.73 ± 0.41	4.5 ± 0.2^#	3.0 ± 1.4	24 ± 1.7^#	17 ± 6.6	2.9 ± 0.2^###	4.4 ± 1.4
PtdSer	0.60 ± 0.19	1.0 ± 0.2*	0.17 ± 0.055^###	0.29 ± 0.057*	1.4 ± 0.36^#	1.2 ± 0.13	3.1 ± 0.56^#	3.1 ± 0.43	23 ± 4.4^#	23 ± 2.9
EPA→n-3 DPA
Total PL	7.6 ± 1.5	17 ± 1.7***	2.2 ± 0.44	5.0 ± 0.49**	18 ± 2.2	21 ± 3.3	123 ± 34	149 ± 35	0.59 ± 0.15	0.48 ± 0.12
ChoGpl	2.7 ± 0.53	5.0 ± 0.43**	0.79 ± 0.15	1.4 ± 0.12**	6.5 ± 0.92	6.2 ± 0.91	192 ± 25	178 ± 41	0.36 ± 0.047	0.40 ± 0.09
EtnGpl	5.2 ± 1.3	11 ± 1.5**	1.5 ± 0.36	3.0 ± 0.43**	12 ± 2.5	13 ± 3.5	147 ± 30	153 ± 44	0.49 ± 0.1	0.48 ± 0.13
PtdIns	0.93 ± 0.16	1.4 ± 0.78	0.27 ± 0.045	0.39 ± 0.22	2.3 ± 0.1	1.6 ± 0.77	336 ± 62	260 ± 113	0.21 ± 0.041	0.31 ± 0.15
PtdSer	0.75 ± 0.24	0.88 ± 0.17	0.21 ± 0.068	0.25 ± 0.05	1.8 ± 0.45	1.1 ± 0.11	31 ± 11	20 ± 3.6	2.2 ± 0.6	3.6 ± 0.61*
EPA→DHA
Total PL	3.4 ± 0.67	1.6 ± 0.15*	1.0 ± 0.19	0.45 ± 0.044*	7.9 ± 0.97	1.9 ± 0.3*	0.091 ± 0.0089	0.022 ± 0.0035*	768 ± 72	3,195 ± 583*
ChoGpl	1.6 ± 0.31	0.80 ± 0.069**	0.46 ± 0.089	0.23 ± 0.02**	3.8 ± 0.54	0.98 ± 0.14**	0.30 ± 0.035	0.070 ± 0.01**	233 ± 28	1,010 ± 146**
EtnGpl	3.2 ± 0.78	2.5 ± 0.35	0.92 ± 0.22	0.71 ± 0.1	7.6 ± 1.5	3.1 ± 0.81*	0.13 ± 0.023	0.054 ± 0.017*	556 ± 93	1,370 ± 415*
PtdIns	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
PtdSer	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND

Data are mean ± SD. P values indicated significantly different from vehicle-treated rats; *P < 0.05, **P < 0.01, ***P < 0.001, ^!P = 0.06. P values indicating significant differences between ¹⁴C-DHA-infused and ¹⁴C-EPA-infused rats upon vehicle injection are ^#P < 0.05, ^##P < 0.01, ^###P < 0.001. Total PL, total phospholipids; ND, not detectable.