TABLE 2.

Glycemic control in genetically obese mice

Mice	Plasma Glucose (mg/dl)	Insulin (ng/ml)	HOMA
WT	76 ± 7	1.4 ± 0.31	0.29 ± 0.07
ob/+	87 ± 12	1.12 ± 0.49	0.26 ± 0.12
db/+	83 ± 5	0.96 ± 0.03	0.23 ± 0.09
ob/ob	106 ± 16	3.8 ± 0.55*	0.95 ± 0.09*
db/db	275 ± 28*	8.28 ± 0.76*	5.69 ± 0.9*

Plasma glucose was significantly increased in db/db compared with ob/ob, wild-type (WT), and heterozygous mice. Insulin and HOMA index were significantly higher in both ob/ob and db/db mice compared with WT and heterozygous mice. Values are mean ± SEM. *P < 0.05, 5–7 animals per group.