TABLE 1.
Characteristics of patients in the study
| Parameter | Before Transplantation | 30 Days after Transplantation | 180 Days after Transplantation |
| No. of patients | 13 | ||
| Males/females | 8/5 | ||
| Cause of kidney disease | |||
| Glomerulonephritis | 6 | ||
| Immunoglobulin A nephropathy | 2 | ||
| Thin basement membrane disease | 1 | ||
| Unknown nephritis | 4 | ||
| Living/cadaveric kidney transplantation | 10/3 | ||
| Age (years) | 46.1 ± 11.2 [24–66] | ||
| CYP3A5 polymorphism | |||
| CYP3A5*1/*1 | 2 | ||
| CYP3A5*1/*3 | 6 | ||
| CYP3A5*3/*3 | 5 | ||
| Body weight (kg) | 57.4 ± 11.8 [44.7–83.1] | 54.7 ± 10.2 [40.7–71.9] | 54.0 ± 10.0 [40.7–71.5] |
| White blood cell count (/μl) | 7,022 ± 2,187 [3,290–9,860] | 5,688 ± 1,791 [2,810–8,630] | 4,980 ± 1,846 [2,920–9,270] |
| Hemoglobin (g/dl) | 11.7 ± 1.8 [9.5–16.1] | 10.5 ± 1.5 [8.5–13.9] | 11.7 ± 1.2 [9.1–13.4] |
| C-reactive protein (mg/dl) | 0.08 ± 0.08 [0.01–0.27] | 0.10 ± 0.11 [0.01–0.37] | 0.06 ± 0.09 [0.01–0.35] |
| ALT (IU/l) | 15.9 ± 12.5 [4.6–44.6] | 14.3 ± 10.8 [4.0–32.6] | 13.4 ± 8.6 [5.8–32.5] |
| γ-GTP (IU/l) | 20.8 ± 9.4 [10.3–35.4] | 23.6 ± 10.1 [10.3–43.5] | 26.6 ± 12.0 [10.4–52.9] |
| Total bilirubin (mg/dl) | 0.44 ± 0.14 [0.28–0.70] | 0.39 ± 0.10 [0.26–0.60] | 0.46 ± 0.16 [0.27–0.74] |
| Blood urea nitrogen (mg/dl) | 52.9 ± 17.2 [28.5–100.7] | 24.3 ± 6.6†† [12.7–38.5] | 25.9 ± 5.2†† [18.8–35.0] |
CYP, cytochrome P450; ALT, alanine aminotransaminase; γ-GTP, γ-glutamyl transpeptidase. Data are expressed as numbers or mean ± SD [range]. †P < 0.01 versus before kidney transplantation.