Fig. 3.
Effects of rosuvastatin on homocysteine-induced expression of MMP-2 in VSMC culture medium
As determined by Western blotting, rosuvastatin (10−9–10−5 mol/L) significantly and dose-dependently decreased the production of MMP-2 in cultured VSMCs induced by 1 000 μmol/L homocysteine. Columns indicate protein expression as a percentage of the 72 h intervention group (0 mol/L rosuvastatin), and represent the mean±SE for three separate experiments performed in duplicate. The group treated with 0 mol/L rosuvastatin and 1 000 μmol/L homocysteine was regarded as the control. & P<0.05, * P<0.01, # P<0.001, vs. control group