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. 2013 Aug 7;4:80. doi: 10.3389/fpsyt.2013.00080

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Copyright © 2013 Raabe and Spengler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experience-dependent epigenetic programing of Crh. Prenatal, postnatal, and adult mice or rats were exposed to different stress paradigms (chronic variable, maternal separation, or social intruder stress). Sexes are indicated by respective symbols. Results from Crh promoter methylation and expression are depicted for the paraventricular nucleus (PVN) and the central amygdala (CeA). Tissues were isolated under resting conditions or following application of an acute stressor. Arrows show increased, decreased, and unaltered CpG methylation and Crh mRNA expression, respectively, for the indicated brain regions. Non-determined (n.d.) refers to the absence of information. In sum, epigenetic programing of Crh occurs in a stressor-, sex-, and tissue-specific manner.