Table 1. Baseline characteristics of the men and women in the study according to incident fracture during follow-up.
| Men (n=1087) | Women (n=1050) |
|||||
|---|---|---|---|---|---|---|
| Incident fracture (n=47) |
No fracture (n=1040) |
P value | Incident fracture (n=116) |
No fracture (n=934) |
P value | |
| Age (yrs), mean (SD) | 64.9 (2.66) | 65.7 (2.91) | 0.081 | 66.9 (2.60) | 66.4 (2.72) | 0.065 |
| BMI (kg/m2), median (IQR) |
25.5 (23.8, 28.5) | 26.7 (24.6, 29.2) | 0.091 | 27.8 (24.5, 31.9) | 26.8 (23.8, 29.9) | 0.039 |
| Habitual physical activity1, mean (SD) |
61.2 (16.3) | 61.5 (15.0) | 0.926 | 59.4 (16.4) | 59.7 (15.0) | 0.838 |
| Alcohol intake (units/wk), median (IQR) |
10.5 (3.25, 23) | 9.05 (3, 19.9) | 0.519 | 3 (0.51, 7.32) | 2.76 (0.5, 7) | 0.382 |
| Calcium intake (mg/wk), median (IQR) |
8134 (6664, 10014) |
8323 (6952, 9941) |
0.809 | 7999 (6579, 9958) |
7860 (6709, 9446) |
0.739 |
| Smoking status, no (%) |
||||||
| Never | 8 (17.0) | 398 (38.3) | 0.002 | 70 (60.3) | 592 (63.4) | 0.402 |
| Ex | 35 (74.5) | 508 (48.9) | 38 (32.8) | 256 (27.4) | ||
| Current | 4 (8.51) | 134 (12.9) | 8 (6.90) | 86 (9.21) | ||
| Had fracture since age 45, no (%) |
13 (27.7) | 128 (12.3) | 0.002 | 52 (44.8) | 175 (18.7) | <0.001 |
| Had fall in the last year, no (%) |
3 (13.0) | 88 (14.6) | 0.826 | 38 (34.9) | 171 (20.3) | 0.001 |
| HADS depression score, no (%) |
0.185 | |||||
| 0-7 | 44 (93.6) | 1009 (97.0) | 109 (9.3.4) | 886 (94.9) | 0.739 | |
| 8-10 (possible depression) |
3 (6.38) | 24 (2.31) | 6 (5.17) | 36 (3.85) | ||
| ≤11 (probable depression) |
0 | 7 (0.67) | 1 (0.86) | 12 (1.28) | ||
| HADS anxiety score, no (%) |
||||||
| 0-7 | 37 (78.7) | 908 (87.3) | 0.014 | 85 (73.3) | 712 (76.2) | 0.667 |
| 8-10 (possible anxiety) |
4 (8.51) | 91 (8.75) | 17 (14.7) | 133 (14.2) | ||
| ≤11 (probable anxiety) |
6 (12.8) | 41 (3.94) | 14 (12.1) | 89 (9.53) | ||
| Taking antidepressants, no (%) |
0 | 18 (1.73) | 0.363 | 10 (8.62) | 37 (3.96) | 0.022 |
| Taking anxiolytics/sedatives/, no (%) |
1 (2.13) | 17 (1.63) | 0.796 | 7 (6.03) | 50 (5.35) | 0.760 |
| Taking bisphosphonate drugs, no (%) |
0 | 3 (0.29) | 0.712 | 2 (1.72) | 28 (3.00) | 0.437) |
1
Standardised score ranging from 0 to 100 derived from frequency of gardening, housework, climbing stairs and carrying loads in a typical week. Higher scores indicate greater level of activity
2
Data on history of falls were collected part way through the study so are available for a subset only; percentages with a history of falls are based on the following numbers: men with no fracture n=599, men with fracture=23; women with no fracture=842, women with fracture=108)