Figure 3.

Connecting intra- and inter-tumour heterogeneity. (Top) Multiple subclones exist in an individual lung tumour each being represented by a different subtype of lung cancer. (Bottom) Some subtypes of lung cancer are more sensitive to therapy than others. This is reflected in an individual tumour for which a therapy selects the most aggressive subclone, such as the subclone resembling the most aggressive cancer subtype.